IL1RA, Recombinant, Human, aa26-177
Catalog Number:
USB-552028
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| Article Name: | IL1RA, Recombinant, Human, aa26-177 |
| Biozol Catalog Number: | USB-552028 |
| Supplier Catalog Number: | 552028 |
| Alternative Catalog Number: | USB-552028-50,USB-552028-100 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| IL-1RA/IL-1F3, also known as interleukin-1 receptor antagonist, is a glycosylated protein and a powerful antiinflammatory agent. IL-1RA is a pan-physiological inhibitor of IL-1 that prevents the activation of IL-1 receptors by inhibiting IL-1 binding to its receptors. It can inhibit angiogenesis by blocking the activation of the IL-1/PI3K/NF-kappaB pathway in IL-1-producing human colon cancer cells. Also, Several autoimmune and inflammatory diseases have been associated with an allelic polymorphism of the IL-1RA. Recombinant human IL1RA was expressed in E. coli and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa26-177 from human IL1RA, expressed in E. coli. AA Sequence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE Biological Activity: The activity is determined by the IFN-g ELISA in a using NK-92 human natural killer cells. The ED50 range 10ng/ml. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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