Natural antibiotic produced by Streptomyces lydicus, known for inhibiting bacterial RNA synthesis by binding to RNA polymerase, making it a valuable tool in research for studying cellular processes like gene expression and bacterial infections. Inhibits bacterial RNA polymerase (not eukaryotic), blocking nucleic acid chain elongation and RNA synthesis. Used to study RNA polymerase function, protein kinase C, and as an antimicrobial agent. Synonym: (2S)-2-[(2S,4E)-4-[(2E,4E,6R)-6-[(1R,2S,3R,5R,6R)-2,5-dimethylspiro[4,9-dioxabicyclo[3.3.1]non-7-ene-6,2-oxirane]-3-yl]-1-hydroxy-4-methylhepta-2,4-dienylidene]-1-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]-3,5-dioxopyrrolidin-2-yl]-N-methylpropanamide, Antibiotic D-45, Portamycin, NSC 3360 CAS No: 7229-50-7 Molecular Formula: C32H44N2O9 Molecular Weight: 600.70 Purity: 98% Appearance: White to off-white powder Solubility: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C for 6 months after receipt. Protect from light and air.
Molecular Weight:
600.7
CAS Number:
[7229-50-7]
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