| Phaseollin is an isoflavonoid phytoalexin that can be isolated from Phaseolus vulgaris. Phaseollin is toxic to bean hypocotyl and endocarp cells, and causes a complete lysis of sheep erythrocytes. Phaseollin is a plant protein that is found in the seeds of the chenopodium plant. It is a potent inducer of the signal peptide, which is a type of protein that directs newly synthesized proteins to their destination organelle. Phaseollin has been shown to be structurally similar to other seed storage proteins and has been reported to have enzyme activities. Molecular docking analysis has shown phaseolin to bind DNA by electrostatic interactions and hydrophobic interactions. This binding prevents the binding of other enzymes or proteins, blocking transcription and translation. Phaseolin also contains disulfide bonds, which are necessary for proper functioning. The absence of these bonds can lead to improper folding and malfunctioning of the protein as well as decreased stability in different environments. Phaseolin can also be broken down by heat or water vapor, so it should be stored at low temperatures with minimal exposure to either one. Synonyms: (2R,11R)-17,17-dimethyl-4,12,18-trioxapentacyclo[11.8.0.02,11.05,10.014,19]henicosa-1(13),5(10),6,8,14(19),15,20-heptaen-7-ol, CHEMBL448350, 3H,7H-Furo(3,2-c:5,4-f)bis(1)benzopyran-10-ol, 6b,12b-dihydro-3,3-dimethyl-, cis- CAS No: 13401-40-6 Molecular Formula: C20H18O4 Molecular Weight: 322.35 Appearance: White to off-white powder Purity: 98% (HPLC) NMR: Conforms to reference Melting Point: 177-178C(lit.) Solubility: As reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
