RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation., May play roles in cilia formation and/or maintenance. Recombinant protein corresponding to aa1-538 from mouse 60kD SS-A/Ro ribonucleoprotein, fused to His-Tag at N-terminal, expressed in E.coli. Amino Acid Sequence: MEGSANQLQP LSETQVVNSE GGCVWQVTDM NRLRRFLCFG SEGGTYYIKE QKLGLENAEA LIRLIEDGRG CEVIQEIKSF SQEGRTAKQE PLLFALAVCS QCADINTKQA AFKAVPEVCR IPTHLFTFIQ FKKDLKESMK CGMWGRALRK AVADWYNEKG GMAVALVVTK YKQRNGWSHK DLLRLSHLKP SSEGLAIVTK YITKGWKEVH EEYKEKALSV EAEKLLKYLE AVEKVKRTKD DLEVIHLIEE HQLVREHLLT NHLKSKEVWK ALLQEMPLTA LLRNLGKMTA NSVLEPGNSE VSLICEKLSN EKLLKKARIH PFHVLIALET YRAGHGLRGK LKWIPDKDIL QALDAAFYTT FKTVEPTGKR FLLAVDVSAS MNQRALGSVL NASTVAAAMC MVVTRTEKES SVVAFACDMV PFPVTTDMTL QQVLTAMNKV PAGNTDCSLP MIWAQKTDTA ADVFVVFTDN ETFAGQVHPA VALREYRKKM DIPAKLIVCG MTSNGFTIAD PDDRGMLDMC GFDTAALDVI RNFTLDVI Molecular Weight: ~60kD Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.
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