ICP47 Protein, Recombinant, Human herpesvirus 1, aa1-88, His-Tag

Product Overview

• Article Name: ICP47 Protein, Recombinant, Human herpesvirus 1, aa1-88, His-Tag
• Biozol Catalog Number: USB-584922
• Supplier Catalog Number: 584922
• Alternative Catalog Number: USB-584922-20,USB-584922-100
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes. Source: Recombinant protein corresponding to aa1-88 from Human herpesvirus 1 ICP47 protein, fused to 10X His-Tag at N-terminal, expressed in E.coli. Molecular Weight: ~13.3kD Amino Acid Sequence: MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLRSPGLLPEIAPNASLGVAHRRTGGTVTDSPRNPVTR Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 13.3
• UniProt: P03170
• Purity: 85% (SDS-PAGE)
• Form: Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.