Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b, Recombinant, Human, aa46-217

Product Overview

• Article Name: Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b, Recombinant, Human, aa46-217
• Biozol Catalog Number: USB-585217
• Supplier Catalog Number: 585217
• Alternative Catalog Number: USB-585217-20,USB-585217-100
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. Source: Recombinant protein corresponding to aa46-217 from human Low affinity immunoglobulin gamma Fc region receptor II-b, fused to 6X His-Tag at C-terminal, expressed in Mammalian cell. Molecular Weight: ~21.6kD Amino Acid Sequence: APPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAP Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 21.6
• UniProt: P31994
• Purity: 85% (SDS-PAGE)
• Form: Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.