Sodium Channel Protein Type 1 Subunit Alpha, Recombinant, Human, aa1-128, His-Tag

Product Overview

• Article Name: Sodium Channel Protein Type 1 Subunit Alpha, Recombinant, Human, aa1-128, His-Tag
• Biozol Catalog Number: USB-586370
• Supplier Catalog Number: 586370
• Alternative Catalog Number: USB-586370-20,USB-586370-100
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli. Source: Recombinant protein corresponding to aa1-128 from human Sodium channel protein type 1 subunit alpha, fused to 6X His-Tag at N-terminal, expressed in E.coli. Molecular Weight: ~18.5kD Amino Acid Sequence: MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHS Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 18.5
• UniProt: P35498
• Purity: 85% (SDS-PAGE)
• Form: Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.