Altersolanol A is a phytotoxic tetrahydroanthraquinone isolated from a number of plant pathogens belonging to the genera Alternaria, Phomopsis, Dactylaria, Stemphylium, Ampelomyces and Pleospora. Altersolanol A is a potent stimulator of NADH oxidation in mitochondria and exhibits potent in vitro cytotoxicity against a broad range of human cancer cell lines. Altersolanol A acts as a kinase inhibitor, induces cell death by apoptosis through the cleavage of caspase-3 and -9 and decreases anti-apoptotic protein expression. Source: Sarocladium sp. Synonyms: NSC 173943, Stemphylin CAS No: 22268-16-2 Molecular Formula: C16H16O8 Molecular Weight: 336.3 Appearance: Orange solid Solubility: Methanol, DMSO. Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with methanol or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight:
336.3
CAS Number:
[22268-16-2]
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