Amphotericin B is a polyene antifungal agent for yeast, mold and mycoplasma. It was first isolated by Gold, et a., from Streptomyces nodosus in 1955. It is an amphoteric compound composed of a hydrophilic polyhydroxyl chain along one side and a lipophilic polyene hydrocarbon chain on the other. Amphotericin B is poorly soluble in water. Amphotericin B binds to sterols, preferentially to the primary fungal cell membrane sterol, ergosterol. This binding disrupts osmotic integrity of the fungal membrane, resulting in leakage of intracellular potassium, magnesium, sugars, and metabolites and then cellular death. Used in the preparation of baculoviral stocks. Synonyms: Abelcet, Abelecet, AmBisome, Ampho-Moronal, Amphocin, Amphozone, Apothecon, Fungilin, Fungizona, Fungizone, Halizon, LNS-AmB, NS 718, NSC 527017 CAS No: 1397-89-3 Molecular Formula: C47H73NO17 Molecular Weight: 924.09 Appearance: Supplied as a yellow to orange powder. Potency: 750ug Amphotericin B/mg Identification (FAB/MS): Conforms to reference Identification A (UV 240-320nm): Conforms to reference Identification B (UV/Vis 320-400nm): Conforms to reference Amphotericin A: 15% Loss on Drying: 5% Residue on Ignition: 3% Residual Solvents: Ethanol: 5% Acetone: 5% Total Aerobic Count: 100 cfu/g Salmonella Species: Negative E. coli: Negative Endotoxin: 2Eu/mg Solubility: Soluble in DMSO and DMF/HCl Amphotericin B is poorly soluble in water. Storage: Store at 4C. Light sensitive. Meets or exceeds USP specifications.
Molecular Weight:
924.09
Purity:
Potency: 750ug Amphotericin B/mg
Form:
Yellow to orange powder
CAS Number:
[1397-89-3]
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