Antibiotic UCN-01 (7-Hydroxystaurosporine, UCN-01), CAS [[112953-11-4]]
Biozol Catalog Number:
USB-A2297-39
Supplier Catalog Number:
A2297-39
Alternative Catalog Number:
USB-A2297-39-1
Manufacturer:
US Biological
Category:
Biochemikalien
Isolated from Streptomyces sp., Antibiotic UCN-01 inhibits protein kinase C (PKC) and cyclin-dependent kinase 2 (CDK2) resulting in accumulation of cells in the G1 phase and induction of apoptosis. UCN-01 also enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by these anti-cancer agents. Solubility: Soluble in ethyl ethanol, DMF or DMSO. Storage and Stability: Lyophilized powder may be stored at -20C. Reconstitute to nominal volume. Aliquot and store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light.
Molecular Weight:
482.5
Purity:
98% by HPLC.
Form:
Supplied as a light tan solid.
CAS Number:
[112953-11-4]
* VAT and and shipping costs not included. Errors and price changes excepted
