Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung. It inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins (e.g., CD11b). Recombinant Bovine Aprotinin is approximately 6.51kD highly purified and designed specifically for cell culture applications, protein purification, diagnostic testing and pharmaceuticals. It is produced without the use of animal- or human-derived materials and is therefore free from risk of contaminating human or animal-derived viruses or prions. Source: Recombinant protein corresponding to bovine Aprotinin. Synonyms: Pancreatic Trypsin Inhibitor CAS No: 9087-70-1 Molecular Formula: C284H432N84O79S7 Molecular Weight: 6.51kD Appearance: Lyophilized powder Solubility: Water: 100mg/ml (15.35mM) Antibiotic Titer: ~3.12EPU/mg Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
6.51
CAS Number:
[9087-70-1]
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