ATP-Citrate Lyase, NT GST-Tag, Recombinant, Human (ACLY, ATP Citrate (pro-S) Lyase, ATP Citrate Synthase, Citrate Cleavage Enzyme, EC 2.3.3.8)
Catalog Number:
USB-A4001-35R
- Images (0)
| Article Name: | ATP-Citrate Lyase, NT GST-Tag, Recombinant, Human (ACLY, ATP Citrate (pro-S) Lyase, ATP Citrate Synthase, Citrate Cleavage Enzyme, EC 2.3.3.8) |
| Biozol Catalog Number: | USB-A4001-35R |
| Supplier Catalog Number: | A4001-35R |
| Alternative Catalog Number: | USB-A4001-35R-10 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Human ATP citrate lyase (ACLY) full length, with N-terminal GST tag, expressed in baculovirus expression system. Accession: NM_001096. Full length enzyme corresponding to aa2-110 of human ATP citrate lyase (ACLY) with N-terminal GST tag, expressed in baculovirus expression system. Accession: NM_001096. Specific Activity: 300pmole/min/ug Assay Condition: Performed with ACLY titrated from 120ng/rxn to 0ng/rxn in 2-fold dilutions. Applications: Suitable for use in enzyme kinetics, inhibitor screening and selectivity profiling. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
Product Guarantee and Expert Support
