Bax, Recombinant, Mouse (BCL2-associated X protein, Apoptosis regulator BAX)
Biozol Catalog Number:
USB-B0175-17
Supplier Catalog Number:
B0175-17
Alternative Catalog Number:
USB-B0175-17-10
Manufacturer:
US Biological
Category:
Molekularbiologie
Bcl-2-associated X protein (Bax) belongs to the Bcl-2 protein family. Bax is a pro-apoptotic Bcl-2 protein containing BH1, BH2 and BH3 domains. Bax accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor bcl2 or its adenovirus homolog e1b 19k protein. Bax induces the release of cytochrome c, activation of casp3, and thereby apoptosis. Bax is expressed in a wide variety of tissues, with highest levels in the testis and ovary. Tumor suppressor protein p53 upregulates the expression of BAX. Bax has been shown to be involved in p53-mediated apoptosis. Recombinant protein corresponding to mouse Bax, amino acids 38-171, expressed in E.coli, is a single, non-glycosylated polypeptide chain. Recombinant Mouse Bax is purified by proprietary chromatographic techniques. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
