Human brain natriuretic peptide (BNP) is a secreted protein which is a member of the natriuretic peptide family. BNP is a cardiac hormone, which is synthesized as a pro-hormone (proBNP), and is proteolytically cleaved to release a biologically active fragment (BNP), and an inactive fragment (NT-proBNP) into the circulation. BNP is predominantly secreted from the cardiac ventricles in response to volume and pressure overload, and results in a number of biological activities including natriuresis, diuresis, vasorelaxation, and inhibition of the sympathetic nervous system. A high concentration of BNP in the bloodstream is indicative of heart failure. Applications: Specific methodologies have not been tested using this product. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20C Stable for 12 months after receipt. Reconstitute with 0.1% acetic acid and store at -20C For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
~95% (HPLC)
Form:
Supplied as a lyophilized powder. Reconstitute in 0.1% acetic acid.
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