Cachectic Factor Control, Human, Control Peptide (CF)
Biozol Catalog Number:
USB-C0104-49D
Supplier Catalog Number:
C0104-49D
Alternative Catalog Number:
USB-C0104-49D-100
Manufacturer:
US Biological
Category:
Molekularbiologie
Application:
ELISA
Control Peptide for (affinity purified) and (antiserum). 18-aa peptide of human CF Cancer cachexia is a syndrome of progressive wasting which is believed to be mediated by tumor necrosis factor-alpha, interleukins 1 and 6, and interferon-gamma, and leukemia-inhibitory factor. However, the levels of these putative agents do not correlate with cachexia. Recently, a new circulating tumor factor, termed cachectic factor (CF), has been isolated and characterized from the urine of mice transplanted with adenocarcinoma MAC16 (1). Purified CF, a proteoglycan of relative mol. Wt of ~24kD, produces cachexia in vivo by inducing catabolism of skeletal muscle. CF was also found in urine of cachectic cancer patients. It is not found in normal urine, patient with weight loss due to trauma, and cancer patient with no weight loss (1). CF appears to be ~24 K on SDS-gels. It is a sulfated glycoprotein. The amino acid analyses was determined as: YSP EAA SAP GSG DPS HEA. An antibody raised to the CF also recognized a 69kD band with the same amino acid sequence as the 24 K material. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
Purified.
Form:
Supplied as a lyophilized powder from PBS, 0.05% sodium azide.
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