Calcyphosine, also known as CAPS, is a calcium-binding protein containing four EF-hand domains. CAPS is initially identified as thyroid protein p24 that is found in several epithelium and in some cells of the central nervous system. It may play a role in the regulation of ion transport. In thyroid follicular cells, CAPS is synthesized and phosphorylated in response to stimulation by thyrotropin and cAMP agonists. Source: Recombinant corresponding to aa1-189 from human CAPS, fused to His-tag at N-terminus, expressed in E. coli. Molecular Weight: ~23.1kD Sequences of Amino Acids: MGSSHHHHHH SSGLVPRGSH MDAVDATMEK LRAQCLSRGA SGIQGLARFF RQLDRDGSRS LDADEFRQGL AKLGLVLDQA EAEGVCRKWD RNGSGTLDLE EFLRALRPPM SQAREAVIAA AFAKLDRSGD GVVTVDDLRG VYSGRAHPKV RSGEWTEDEV LRRFLDNFDS SEKDGQVTLA EFQDYYSGVS ASMNTDEEFV AMMTSAWQL Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
