Cathepsin H, Recombinant, Human, aa23-335, His-Tag (CTSH, Cathepsin H Mini Chain, Cathepsin H Heavy Chain, Cathepsin H Light Chain, CPSB)
Biozol Catalog Number:
USB-C2097-62
Supplier Catalog Number:
C2097-62
Alternative Catalog Number:
USB-C2097-62-10
Manufacturer:
US Biological
Category:
Molekularbiologie
Cathepsin H is a lysosomal cysteine protease of the papain family. It is synthesized as a precursor protein that is proteolytically processed to a mature form consisting of a light chain, a heavy chain, and a minichain. Cathepsin H is the only known monoaminopeptidase in the papain family. Cathepsin H is primarily an aminopeptidase, but also functions as an endopeptidase. Cathepsin H is potently inhibited by cystatins A, B, and C and by ovocystatin. Cathepsin H expression is altered in disease states such as prostate and colorectal cancers. Source: Recombinant corresponding to aa23-335 from human Cathepsin H fused to 10-His-tag at C-terminal expressed in CHO cell line. Molecular Weight: ~37kD Biological Activity: Measured by its ability to cleave the fluorogenic peptide substrate, Arg7amido4methylcoumarin (RAMC). Specific Activity: >750 pmol/min/ug, as measured under the described conditions. Endotoxin: ~1EU/1ug (LAL) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
