CD61 (Integrin beta 3 (Platelet Glycoprotein IIIa, Antigen CD61), Integrin beta-3, ITGB3, Platelet Membrane Glycoprotein IIIa, GP3A, GPIIIa) (FITC), Clone: [HMb3-1], Hamster, Monoclonal
Catalog Number:
USB-C2414-21C-FITC
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| Article Name: | CD61 (Integrin beta 3 (Platelet Glycoprotein IIIa, Antigen CD61), Integrin beta-3, ITGB3, Platelet Membrane Glycoprotein IIIa, GP3A, GPIIIa) (FITC), Clone: [HMb3-1], Hamster, Monoclonal |
| Biozol Catalog Number: | USB-C2414-21C-FITC |
| Supplier Catalog Number: | C2414-21C-FITC |
| Alternative Catalog Number: | USB-C2414-21C-FITC-100 |
| Manufacturer: | US Biological |
| Host: | Hamster |
| Category: | Antikörper |
| Application: | FC, IHC |
| Immunogen: | Recombinant protein corresponding to mouse Integrin beta-3. |
| The integrin family of cell adhesion receptors consists of several membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. Platelet membrane glycoprotein Integrin beta3 or CD61 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets. Applications: Suitable for use in Immunohistochemistry, Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 0.1-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse bone marrow-derived cells. Storage and Stability: Store product at 4C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20C. Aliquots are stable at -20C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody. |
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