CD80 IgG2a Fc & Hinge Region, Fusion Protein (B7-1 Costimulator Protein) (Biotin)

Product Overview

• Article Name: CD80 IgG2a Fc & Hinge Region, Fusion Protein (B7-1 Costimulator Protein) (Biotin)
• Biozol Catalog Number: USB-C2432-01J
• Supplier Catalog Number: C2432-01J
• Alternative Catalog Number: USB-C2432-01J-25
• Manufacturer: US Biological
• Category: Molekularbiologie
• Application: ELISA, FC

Product Description

CD80, also known as BB1/B7-1, is a 60kD type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed on activated B cells, T cells, monocytes and dendritic cells. It is a ligand of the two T cell costimulatory molecules, CD28 and CD152 (CTLA-4). The interaction of CD80 (or CD86) with CD28 provides a costimulatory signal for T cells activated through the CD3/TCR complex. Transfectant Cell Line: CHO Functional Application: CD80-muIg fusion protein blocks binding of anti-human CD80 to human tumor cells. Human CD80-muIg/Biotin Fusion Protein* Molecular Structure: A soluble dimeric fusion protein consisting of the extracellular (173aa) domain of human CD80 fused to murine IgG2a Fc + hinge (232 aa). Predicted monomeric molecular weight: 51.3kD. Applications: Suitable for use in ELISA, Flow cytometry. Other applications not tested. Recommended Dilution Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 51.3
• Purity: Purified by Protein A affinity chromatography.
• Form: Supplied as a liquid in FBS, 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% NaN3.