Chaetocin is an epithiodioxopiperazine antibiotic that has recently shown promise as a selective antitumor agent. Chaetocin is a specific inhibitor for the lysine-specific methyltransferase SU(VAR)3-9 both in vitro and in vivo. Chaetocin is dramatically accumulated in cancer cells via a process inhibited by glutathione. Inside the cell, its activity is mediated by the imposition of oxidative stress. DMSO, DMF, methanol and ethanol. Poorly soluble in water
Molecular Weight:
696.85
Purity:
> 99% by HPLC
Form:
White solid
CAS Number:
[28097-03-2]
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