2-Chloro-5-nitro-N-4-pyridinylbenzamide (T0070907), CAS [[313516-66-4]]

Product Overview

• Article Name: 2-Chloro-5-nitro-N-4-pyridinylbenzamide (T0070907), CAS [[313516-66-4]]
• Biozol Catalog Number: USB-C5029-18
• Supplier Catalog Number: C5029-18
• Alternative Catalog Number: USB-C5029-18-5,USB-C5029-18-10,USB-C5029-18-25
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARgamma with a Ki of 1nM. Displays >800-fold greater selectivity for PPARgamma over PPARalpha and PPARdelta (Ki = 0.85uM and 1.8uM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARgamma and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARgamma2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain. Alternate Names: T0070907 CAS Number: 313516-66-4 Molecular Weight: 277.66 Appearance: Supplied as a light orange solid. Molecular Formula: C12H8ClN3O3 Solubility: DMSO (Slightly), Methanol (Slightly) Melting Point: >184C (dec.) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 277.66
• CAS Number: [313516-66-4]