Protease inhibitor produced by Actinomycetes. Inhibits serine and cysteine proteases: a, b, g, d chymotrypsin, papain, cathepsin A, B and C. Mixture of Types A, B and C where A=Leu, B= Val, C= Ile. Mostly Type A. Synonyms: (S)-1-Carboxy-2-phenylethyl)-carbamoyl-alpha-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal CAS No: 9076-44-2 Molecular Formula: C31H41N7O6 Molecular Weight: 604.9 Appearance: White to off-white powder Solubility (10mg/ml, glacial acetic acid): Colorless to yellow, clear, complete Percentage of X Components: Leu: ~75% Val: ~20% Ile:~5% Activity (IC50) (alpha-chymotrypsin/casein, pH 7.4, 37C): ~0.2ug/ml Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile glacial acetic acid. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Molecular Weight:
604.9
Form:
White to off-white powder
CAS Number:
[9076-44-2]
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