CIDE-A, CT, Blocking Peptide (Cell Death-inducing DFF-like Effector A)
Biozol Catalog Number:
USB-C5072-01P
Supplier Catalog Number:
C5072-01P
Alternative Catalog Number:
USB-C5072-01P-50
Manufacturer:
US Biological
Category:
Molekularbiologie
Peptide corresponding to amino acids 200 to 217 of human CIDE-A (5). Apoptosis is related to many diseases and induced by a family of cell death receptors. Cell death signals are transduced by DD-, DED-, or CARD-containing molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase DFF40/CAD, which is chaperoned and inhibited by DFF45/ICAD (1-4). DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified (5). CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD (5,6). Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is expressed in many tissues.
Purity:
Purified
Form:
Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.
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