Anti-cancer compound. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Anti-inflammatory compound. Suppresses monosodium urate crystal-induced NLRP3/NALP3 inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils at micromolar concentrations. Blocks the release of a crystal-derived chemotactic factor from neutrophil lysosomes, blocks neutrophil adhesion to, and inhibits monosodium urate crystal-induced production of superoxide anions from neutrophils at nanomolar concentrations. Drug used in treatment of gout, familial Mediterranean fever, pericarditis and Behects disease. Investigated for its anti-cancer activity. It has a narrow therapeutic index with no clear-cut distinction between nontoxic, toxic and lethal doses, causing substantial confusion among clinicians. Apoptosis inducer in a variety of normal and tumor cell lines. Synonyms: (-)-Colchicine, NSC 757, EINECS 200-598-5, N-[(7S)-1,2,3,10- tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen- 7-yl]acetamide CAS Number: 64-86-8 Source: Colchicum autumnale Molecular Weight: 399.4 Molecular Formula: C22H25NO6 Purity (HPLC): Content of Colchicine: 94-101% (HPLC) Chromatographic Purity: 95% (HPLC) Appearance: Pale yellow to green crystalline powder Melting Point: 155-157C Optical Rotation: [a]D20 = -240 to -250 (C=1 in EtOH) Water (KF): 2% E. coli, Salmonella, S. aureus: Negative Yeast and Mold: 100cfu/g Microbial Count: 1000cfu/g (TPC) Related Substances: Total Impurity: 5% Residual Solvents: Limit of Colchicine: Complies Limit of Ethylacetate: 8% Chloroform: 100ppm Methylene chloride: 600ppm Methanol: 3000ppm Hexane: 290 ppm Solubility: 100% ethanol (>100mg/ml), DMSO (>100mg/ml), water or DMF Storage and Stability: Store at 4C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
399.4
CAS Number:
[64-86-8]
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