Human C9 is a soluble glycoprotein of 61kD. It is the last component in the assembly of the membrane attack complex (MAC). When the complement is activated on target membranes, multiple copies of C9 bind to the C5b-8 complex and assemble the barrel-shaped pore which causes cell lysis. The conformation of C9 changes from globular to a tubular form. The binding of C9 to C5b-8 plays a key role in the function of C9. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry, ELISA, and inhibition of C9 binding to C5b-8. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1:10 Western Blot: 1:10 Immunohistochemistry (Frozen and paraffin): 1:10 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clonality:
Monoclonal
Clone Designation:
[9G176 X197]
Isotype:
IgG1
Purity:
Purified by Protein G affinity chromatography.
Form:
Supplied as a liquid in PBS, 0.1% BSA.
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