CRK, Recombinant, Human, aa1-204, His-Tag (Adapter Molecule crk, Proto-oncogene c-Crk, p38)

Product Overview

• Article Name: CRK, Recombinant, Human, aa1-204, His-Tag (Adapter Molecule crk, Proto-oncogene c-Crk, p38)
• Biozol Catalog Number: USB-C7924-11
• Supplier Catalog Number: C7924-11
• Alternative Catalog Number: USB-C7924-11-10,USB-C7924-11-50
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

CRK is a member of signaling adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein is involved in many cellular processes including apoptosis, proliferation, and differentiation. It has a modular domain architecture consisting of an SH2 followed by two SH3 domains (src-homology domains). The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Recombinant protein corresponding to aa1-204 of human CRK protein, fused to His-tag at N-terminus, expressed in E.coli. Accession Number: NP_005197 Molecular Weight: ~25kD (224aa) confirmed by MALDI-TOF Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG MIPVPYVEKY RPASASVSAL IGGR Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 25
• NCBI: 005197
• UniProt: P46108
• Purity: 95% (SDS-PAGE).
• Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 10% glycerol.