Cyclic GMP (cGMP) Protein Kinase Substrate [Arg-Lys-Arg-Ser-Arg-Lys-Glu]

Product Overview

• Article Name: Cyclic GMP (cGMP) Protein Kinase Substrate [Arg-Lys-Arg-Ser-Arg-Lys-Glu]
• Biozol Catalog Number: USB-C8451-07C
• Supplier Catalog Number: C8451-07C
• Alternative Catalog Number: USB-C8451-07C-1
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Sequence (linear): Arg-Lys-Arg-Ser-Arg-Lys-Glu Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG). Storage and Stability: Lyophilized powder may be stored at 4C for short-term only. Stable for 12 months at -20C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Purity: 95+% HPLC, Mass Spec
• Form: Supplied as a white to off-white lyophilized powder.