Cyclosporin D, Val2 (Val2-cyclosporine (Val2)DH-CS), CAS [[63775-96-2]]

Product Overview

• Article Name: Cyclosporin D, Val2 (Val2-cyclosporine (Val2)DH-CS), CAS [[63775-96-2]]
• Biozol Catalog Number: USB-C8901
• Supplier Catalog Number: C8901
• Alternative Catalog Number: USB-C8901-1,USB-C8901-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

The pharmacological profiles of two new derivatives of the immunosuppressive drug, cyclosporine, is presented here. (Nva2)-CS has very similar properties to CS, but lacks the nephrotoxic side-effects. This derivative appears to be a potential successor to cyclosporine. (Val2)DH-CS seems to have a different spectrum of activities. It does not suppress humoral immunity and allograft rejection, but suppresses some types of cell-mediated immune responses. This derivative may prove useful in autoimmune situations where T cells are involved in the disease process. Synonyms: Val2-cyclosporine, Cyclosporin D, Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl, 7-L-valine-cyclosporin A CAS No: 63775-96-2 Molecular Formula: C63H113N11O12 Molecular Weight: 1216.64 Appearance: White solid Purity (HPLC): 95% Melting Point: >136C (dec.) Solubility: Chloroform (Sparingly), Ethyl Aceatate (Slightly), Methanol (Slightly) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 1216.64
• Purity: 95% (HPLC)
• Form: White solid
• CAS Number: [63775-96-2]