Cytomegalovirus (CMV) antigen is considered one of the most common viral infections in man. The virus rarely causes disease, but may persist as a latent or chronic infection of the salivary glands, renal tubules, cervix and leukocytes. CMV infections are frequent and occasionally severe in children or adults with congenital or acquired defects of cellular immunity, such as patients with AIDS, cancer and recipients of organ transplants. The transmission of CMV via transfused blood may account for the majority of the CMV infections in organ transplant recipients, neonates and heart surgery patients. Medical conditions resulting from Cytomegalovirus infections include: interstitial pneumonia, mononucleosis (heterophile negative), congenital defects, abortion, mental retardation, blindness and deafness. The new CMV Grade III antigen C9100-03F is purified by column chromatography to enrich for pp65 along with other CMV antigens. The chromatography purified CMV Grade III has a higher specific activity after the removal of impurities and strong reactivity for both IgG and IgM sera. Source: Cytomegalovirus, Strain AD169, propagated in human fibroblast cells. Inactivation: Ultraviolet light Applications: Suitable for use in solid phase immunoassays. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.
Purity:
~60% Viral Protein
Form:
Supplied as a liquid in 0.1M glycine, pH 9.3 - 9.7.
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