DcR2, ID, Blocking Peptide (TRAIL-R4, TRUNDD, Decoy Receptor2, TNF receptor related receptor for TRAIL, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRUNDD, Tumor necrosis factor receptor superfamily
Biozol Catalog Number:
USB-D1500-05P
Supplier Catalog Number:
D1500-05P
Alternative Catalog Number:
USB-D1500-05P-50
Manufacturer:
US Biological
Category:
Molekularbiologie
Peptide corresponding to amino acids 249 to 263 of human DcR2 precursor (4-6). Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1-3). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (4-6). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.
Purity:
Purified
Form:
Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.
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