Doramectin (25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1A, 25-Cylohexyl-avermectin B1, UK-67994, Dectomax), CAS [[117704-25-3]]

Product Overview

• Article Name: Doramectin (25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1A, 25-Cylohexyl-avermectin B1, UK-67994, Dectomax), CAS [[117704-25-3]]
• Biozol Catalog Number: USB-D9025
• Supplier Catalog Number: D9025
• Alternative Catalog Number: USB-D9025-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

Doramectin is a biosynthetic avermectin derived from a mutant of the original Streptomyces avermitilis strain supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite. Melting Point: As Reported Solubility: As Reported Method for Determining Identity: Proton NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis TLC Conditions: As Reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Product Properties

• Molecular Weight: 899.11
• Purity: ~90%
• CAS Number: [117704-25-3]