First purified from clam ganglia, FMRFamide (Phe-Met-Arg-Phe-NH2) is expressed in both invertebrates and vertebrates. Its has been shown to serve various functions in the mammalian nervous system including inhibition of morphine-induced feeding, behavioral effects when administered intrathecally, and to have amnesic effects in rodents. More recently, FMRFamide has been shown to potentiate proton currents and a suggested mode of action is through modulation of ASIC1 and ASIC3. Sequence (linear): Phe-Met-Arg-Phe-NH2 Storage and Stability: Lyophilized powder may be stored at 4C for short-term only. Stable for 12 months at -20C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
95+% HPLC, Mass Spec
Form:
Supplied as a white to off-white lyophilized powder.
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