GADD153, Recombinant, Human (Growth Arrest and DNA Damage-inducible 153, CHOP, DDIT3, CEBPZ, CHOP10, MGC4154 )
Biozol Catalog Number:
USB-G1017-34
Supplier Catalog Number:
G1017-34
Alternative Catalog Number:
USB-G1017-34-100
Manufacturer:
US Biological
Category:
Molekularbiologie
Recombinant GADD153 fused with His-tag, was expressed in E. coli and purified by conventional chromatography techniques GADD153, also known as DNA-damage-inducible transcript 3 (DDIT3), is a basic domain-leucine zipper(bZIP) transcription factor of C/EBP family. This protein has been shown to be up-regulated by several stresses, such as amino acid or glucose starvation, endoplasmic reticulum (ER) stress, osmotic stress and hypoxia. GADD153 protein may play a role in ER stress-mediated apoptosis and in disease including diabetes, brain ischemia and neurodegenerative disease. Molecular Weight: 21kD (189 aa) (Real molecular weight on SDS-PAGE will be shifted up) Sequence: MGSSHHHHHH SSGLVPRGSH MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA Storage and Stability: For long-term storage, aliquot and store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
