Ganglioside GM2, Bovine (Sodium Salt), CAS [[19600-01-2]]
Biozol Catalog Number:
USB-G2006-15
Supplier Catalog Number:
G2006-15
Alternative Catalog Number:
USB-G2006-15-500,USB-G2006-15-1
Manufacturer:
US Biological
Category:
Molekularbiologie
Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane. Gangliosides isolated from apoptogenic glioblastoma multiforme (GBM) cells are enriched in ganglioside GM2 compared with nonapoptogenic GBM cells, and ganglioside GM2 induces activated T cell death when used at a concentration of 150ug/ml in vitro. Serum ganglioside GM2 levels are increased in patients with breast cancer or cholangiocarcinoma. Levels of ganglioside GM2 are elevated in the brain of patients with Sandhoff disease, as well as feline and mouse models of the disease. Ganglioside GM2 accumulates in the lysosomes of individuals with Tay-Sachs disease and GM2-activator deficiency, as well as in the CNS of patients with and animal models of mucopolysaccharide storage disorders and Niemann-Pick disease types A, C1, and C2. G2006-15 contains ganglioside GM2 molecular species with primarily C18:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. CAS No: 19600-01-2 Molecular Formula: C67H120N3O26Na (for stearoyl) Molecular Weight: 1383.7 + 23 (calculated on sphingosine C18:1 and stearic acid) Solubility: Soluble in chloroform/methanol mix (2:1). Also soluble in water. Appearance: Supplied as a solid Purity: 98% Storage and Stability: Store lyophilized powder at -20C under dessicated conditions (protect from moisture). Stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
1406.7
Purity:
98%
CAS Number:
[19600-01-2]
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