Glucagon Like Peptide 1, Recombinant, Human (GLP1)
Biozol Catalog Number:
USB-G2040-13S
Supplier Catalog Number:
G2040-13S
Alternative Catalog Number:
USB-G2040-13S-200,USB-G2040-13S-1
Manufacturer:
US Biological
Category:
Molekularbiologie
GLP-1 is a proglucagon-derived peptide hormone secreted primarily by intestinal L cells during feeding. Its major physiological function is the stimulation of pancreatic beta cells to release appropriate amounts of insulin after glucose absorption. Other biological actions exhibited by GLP-1 include the suppression of plasma glucagon levels, inhibition of gastric motility, and promotion of satiety. The secretion of GLP-1 from intestinal L cells is stimulated by nutrients, hormones, and neural inputs. On the other hand, insulin has been reported to inhibit GLP-1 release, indicating that a feedback loop mechanism regulates GLP-1 secretion. In addition to being the precursor of GLP-1, proglucagon, whose primary structure is highly conserved in mammalian species, is also the precursor for other members of the glucagon family of peptide hormones, including glicentin-related pancreatic peptide (GRPP), glucagons, and GLP-2. Recombinant Human GLP-1 is a 3.3kD polypeptide consisting of 31 amino acid residues. Recombinant protein corresponding to human Glucagon Like Peptide 1, expressed in E. coli. Molecular Weight: ~3.3kD Amino Acid Sequence: HAEGTFTSDV SSYLEGQAAK EFIAWLVKGR G Biological Activity: Not available. Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
