| Hydroxyurea is used as an inhibitor of DNA synthesis. As an anti-neoplastic, hydroxyurea inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. Synonyms: Carbamohydroxamic acid, N-Carbamoylhydroxylamine, N-Hydroxyurea, Biosupressin, Carbamohydroxamic Acid, Carbamoyl Oxime, Cytodrox, Droxia, HU, Hidrix, Hydrea, Hydreia, Hydroxycarbamide, Hydroxycarbamine, N-(Aminocarbonyl)hydroxylamine, Hydroxylurea, Hydura, Hydurea, Litaler, Litalir, N-Carbamoylhydroxylamine, NCI C04831, NSC 32065, Oxyurea, SK 22591, SQ 1089 CAS Number: 127-07-1 Molecular Formula: CH4N2O2 Molecular Weight: 76.06 Appearance: White to off-white crystalline powder Purity: 97%-103% Solubility: Soluble in water, practically insoluble in alcohol, soluble in hot alcohol. Identification (IR): Passes USP Loss on Drying: 0.5% Urea: 0.5% Heavy Metals (Pb): 0.002% Melting Point: 138-145C Related Substances: 0.2% Chloride: 0.005% Storage and Stability: May be stored at 4C. Stable for 12 months after receipt. |
