Interleukin 1 Receptor Type II (IL-1RII), IgG1, Clone: [6D489 MNC2 8-5], Mouse, Monoclonal
Biozol Catalog Number:
USB-I7663-25K3
Supplier Catalog Number:
I7663-25K3
Alternative Catalog Number:
USB-I7663-25K3-100
Manufacturer:
US Biological
Host:
Mouse
Category:
Antikörper
Application:
ELISA, FC, IHC, WB
Immunogen:
Recombinant protein corresponding to human IL-1RII (Interleukin-1 Receptor type II, CD121b).
The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1RI and IL-1RII) and the IL-1 receptor accessory protein. The IL-1RII is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1RI. The decoy IL-1RII can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1RII exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts. Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: ELISA: Capture Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
