IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant murine IL-31 is a 15.8kD protein containing 140 amino acid residues. Amino Acid Sequence: SHTLPVRLL RPSDDVQKI VEELQSLSK MLLKDVEEE KGVLVSQNY TLPCLSPDA QPPNNIHSP AIRAYLKTI RQLDNKSVI DEIIEHLDK LIFQDAPET NISVPTDTH ECKRFILTI SQQFSECMD LALKSLTSG AQQATT Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Purity:
98% by SDS-PAGE and HPLC analyses. Endotoxin: 0.1ng/ug (1EU/ug)
Form:
Supplied as a lyophilized powder from 20mM sodium phosphate, pH 7.5. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml, which can then be further diluted to other aqueous solutions with BSA or HSA.
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