IP-10, Recombinant, Human (Interferon gamma Inducible Protein, CXCL10)
Biozol Catalog Number:
USB-I8449-08N
Supplier Catalog Number:
I8449-08N
Alternative Catalog Number:
USB-I8449-08N-5,USB-I8449-08N-25
Manufacturer:
US Biological
Category:
Molekularbiologie
Among CXC chemokines, CXCL10 has been identified to play an important role in several endocrinological autoimmune diseases such as Hashimotos thyroiditis, Gravesdisease and Type 1 diabetes mellitus.The chemokine IP-10 (interferon-inducible protein of 10 kD, CXCL10) is a chemoattractant for CXCR3+ T cells, binds to the G protein-coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases. IP-10 also binds to glycosaminoglycans (GAGs), an interaction thought to be important for its sequestration on endothelial and other cells Recombinant protein corresponding to human IP-10, expressed in E. coli. Swiss/Uniprot: P02778 Amino Acid Sequence: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP Biological Activity: Determined by its ability to chemoattract human T-Lymphocytes using a concentration of 10-50ng/ml Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O containing 0.1% BSA or HSA. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
