| Coronary vasodilator. Nitric oxide donor. Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin. Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model. It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range. Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris. Synonyms: 1,4:3,6-Dianhydro-D-glucitol Dinitrate, 1,4:3,6-dianhydro-D-glucitol, 2,5-dinitrate, Dinitrosorbide, 1,4:3,6-Dianhydrosorbitol 2,5-Dinitrate, Carvasin, Cedocard, Corovliss, Dignonitrat, Dilatrate, Diniket, ISDN, NSC 80038, SST-101, Dilatrate SR, Korodil, (3R,3aS,6S,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl dinitrate CAS No: 87-33-2 Molecular Formula: C6H8N2O8 Molecular Weight: 236.14 Appearance: White to off-white powder Purity: 98% Solubility: DMSO, Ethanol Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
