Kanamycin sulfate is an antibiotic that belongs to the group of drugs called aminoglycosides. It binds to ribosomal components and inhibits protein synthesis. Kanamycin sulfate appears to prevent bacteria from making their cell walls, thus the cells die. It is used to treat many sensitive gram-negative, some gram-positive bacteria and and mycoplasmas in cell culture. Kanamycin is inactivated by an aminoglycoside phospho transferase (MW 25,000) in the periplasmic space. Suitable for use as a selectable marker for cosmid vectors used in transfection of mammalian cells. Synonyms: O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(16)-O-[6-amino-6-deoxy-alpha-D-glucopyranosyl-(14)]-2-deoxy-D-streptamine Sulfate, Cantrex, Cristalomicina, Enterokanacin, Kamycin, Kanabristol, Kanamytrex, Kanaqua, Kanasig, Kanatrol, Kanescin, Otokalixin, Resistomycin, Amikacin EP Impurity D Sulfate CAS No: 25389-94-0 Molecular Formula: C18H36N4O11H2SO4 Molecular Weight: 582.58 Activity on Dry Basis: 750ug/mg Appearance: White to light tan crystalline powder Identity: To pass USP Test Kanamycin B Content: 4% Specific Rotation: +112 to +123 pH: 7.0-9.0 Sulfate: 15-17% Loss on Drying: 3% Residue on Ignition: 0.5% Endotoxin: 2EU/mg Working Concentration: Cell/Tissue Culture: ~30ug/ml Stringent Plasmids: 10ug/ml Relaxed Plasmids: 50ug/ml Storage and Stability: May be stored at 4C. Stable for 12 months after receipt.
Molecular Weight:
582.58
CAS Number:
[25389-94-0]
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