Lapatinib, Di-p-Toluenesulfonate Salt (N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine Ditosylate, Lapatinib Ditosylate, Tykerb, GW-572016, Tyverb), CAS [[38808

Product Overview

• Article Name: Lapatinib, Di-p-Toluenesulfonate Salt (N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine Ditosylate, Lapatinib Ditosylate, Tykerb, GW-572016, Tyverb), CAS [[38808
• Biozol Catalog Number: USB-L1315-50
• Supplier Catalog Number: L1315-50
• Alternative Catalog Number: USB-L1315-50-100
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Lapatinib inhibits both epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) tyrosine kinases by binding to the intracellular phosphorylation domain, preventing receptor autophosphorylation. The exact site of binding has currently not been confirmed. It appears to arrest the development of breast cancer in some patients with metastatic, treatment-refractory disease. Solubility: Soluble in DMSO at 200mg/ml, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 1-10uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Elemental Anaylsis: Calculated: C=54.22% H=4.76% Cl=3.72% F= 1.99% N=5.88% S= 10.10% Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 6 months after receipt.

Product Properties

• Molecular Weight: 925.46
• Purity: ~99%
• Form: Supplied as a yellow powder.
• CAS Number: [388082-78-8]