Inhibits hepatic gluconeogenesis by activating AMP-activated protein kinase (AMPK). A widely used anti-hyperglycemic (anti-diabetic) agent for the treatment of type 2 diabetes mellitus. Anti-cancer activity of metformin has been attributed to several mechanisms such as inhibition of mammalian target of rapamycin (mTOR), cancer stem cells and inflammation. Synonyms: N,N-Dimethylimidodicarbonimidic Diamide Hydrochloride, Diabetosan, Diabex, Glucophage, Metiguanide, Glucoform, Glucomet, Glucomin, Glucomine, Orabet, Siamformet, Walaphage, Glumetza CAS No: Water Molecular Formula: C4H12ClN5 Molecular Weight: 165.62 Appearance: White to off-white solid Purity: 98% Identity: Conforms to structure Method for Determining Identity: Proton NMR Spectroscopic Analysis TLC Conditions: C18, Acetonitrile: Methanol: Water: Acetic Acid, 5ml: 3ml: 2ml: 10 drops, Visualized with UV and AMCS, Rf=0.5. Melting Point: 216-220C Solubility: Water, Methanol, DMSO (Heated) Chloride: ~20% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
165.62
Purity:
98%
Form:
White to off-white solid
CAS Number:
[1115-70-4]
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