Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0mM (52% inhibition occured at 100mM). Methionine sulfoximine is also a toxic byproduct of nitrogen trichloride, a compound that was used to bleach unprocessed wheat flour prior to 1968. The compound has been investigated as a potential neurotoxin linked to diseases such as amyotrophic lateral sclerosis (ALS) and Parkinsons disease. Synonyms: L-S-[3-Amino-3-carboxypropyl]-S-methyl-[R,S]-sulfoximine, (2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic Acid CAS Number: 15985-39-4 Molecular Formula: C5H12N2O3S Molecular Weight: 180.23 Appearance: White to off-white solid Purity: 98% Melting Point: >210C (dec.) Solubility: Formic Acid, Water Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
180.23
Purity:
98%
Form:
White to off-white solid
CAS Number:
[15985-39-4]
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