Alpha1-microglobulin is a plasma protein synthesized in the liver. It consists of a single polypeptide chain which is synthesized from the same mRNA as bikunin, the light-chain of inter-alpha-trypsin inhibitor. Bikunin is cleaved before the secretion of alpha1-Microglobulin. Alpha1-Microglobulin is strongly associated with a yellow-brown chromophore of unknown structure and about half the plasma alpha1-Microglobulin is convalently linked to monomeric IgA. The plasma concentration range is 20-100mg/L. The function is not known. It has been implicated in immunoregulation and through its translation as a diprotein with bikunin it is associated with proteolysis inhibition. Elevated levels are associated with renal disorders and abnormalities of the renal tubules, elevated plasma IgA. Sub-normal levels are associated with HIV-infection, some liver dysfunctions and decreased plasma IgA. Storage and Stability: May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
2730
Purity:
95% by SDS-PAGE shows a single band consistent with a molecular weight of ~30kD. Immunological identity confirmed by Radial immunodiffusion (RID).
Form:
Supplied as a liquid in 20mM Tris buffer, pH 8.0, 100mM sodium chloride, 0.05% sodium azide.
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