Msx2, also known as HOX-8, is a homeobox containing transcription factor which is a member of the MSH family of homeobox proteins. Homeobox genes (HOX genes), encode DNA binding proteins that recognize specific sequences and modulate transcriptional activity (1). Msx-2 is believed to play a role in regulating bone development, particularly in sutures of cranial bone (5). Msx-2 is also expressed in sites of skin appendage formation and it has been proposed that Msx-2 is involved in the growth of skin and skin appendages (6). Msx2 mRNA is found expressed at higher levels in immature tumors, including a yolk sac tumor, seminoma, and chroiocarcinoma, and also in various tumors of epithelial origin (2). Msx2 gene expression is frequently activated in carcinoma-derived cell lines. The gene is inactive in NIH3T3 cells but is transcriptionally activated after transformation by v-Ki-ras suggesting that the Msx2 may play a role in cell transformation (3). Msx2 defects are a cause of craniosynostosis type 2 (CRS2), a disease that is characterized by premature fusion of calvarial sutures that leads to abnormal skull shape (4). Applications: Suitable for use in ELISA and Antibody Blocking. Other applications not tested. Recommended Dilution: Antibody Blocking: 5-10ug control peptide per 1ug of IgG or 1ul of antiserum Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at 4C for short-term only. Stable for 12 months at -20C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
Highly purified (HPLC, MS)
Form:
Supplied as a lyophilized powder. No preservative added.
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