This 11mer peptide myelin oligodendrocyte glycoprotein ( pMOG) (44-54) represents the core binding epitope for MOG-specific CD8+ T cells. This is the minimal, functionally constant, length of the MOG (35-55) peptide that binds to CD8+ MOG-specific T cells and stimulates T cell proliferation in vitro. MOG peptide (35-55) is highly encephalitogenic and can induce strong T and B cell responses. A single injection of this peptide produces a relapsing- remitting neurologic disease with extensive plaque-like demyelination. Because of the clinical, histophathologic, and immunologic similarities with multiple sclerosis (MS), the MOG induced demyelinating encephalomyelitis may serve as a model for investigating MS. Amino Acid Composition: H-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-OH. Solubility: It is recommended to reconstitute the lyophilized MOG in sterile 18MO-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions. Storage and Stability: Lyophilized powder may be stored at 4C for short-term only. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
1347.6
Purity:
~90% as determined by RP-HPLC, MS
Form:
Supplied as a lyophilized powder without additives.
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