| The aglucon of naringin. Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. It is the predominant flavanone in grapefruit. This substance has also been shown to reduce oxidative damage to DNA in vitro. Scientists exposed cells to 80 micromoles of naringenin per liter, for 24 hours, and found that the amount of hydroxyl damage to the DNA was reduced by 24% in that very short period of time. Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2, which can change pharmacokinetics in a human (or orthologous) host of several popular drugs in an adverse manner, even resulting in carcinogens of otherwise harmless substances. Naringenin has also been shown to reduce hepatitis C virus production by infected hepatocytes (liver cells) in cell culture. This seem to be secondary to Naringenin ability to inhibit the secretion of very-low-density lipoprotein by the cells. Naringenin seems to protect LDLR-deficient mice from the obesity effects of a high-fat diet. Naringenin lowers the plasma and hepatic cholesterol concentrations by suppressing HMG-CoA reductase and ACAT in rats fed a high-cholesterol diet. Synonyms: 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, (R,S)-Naringenin, (+/-)-5,7,4-Trihydroxyflavanone, 5,7,4-Trihydroxyflavanone CAS No: 67604-48-2 Molecular Formula: C15H12O5 Molecular Weight: 272.25 Appearance: Pale yellow to pale brown solid Purity: 98% Melting Point: >252C (dec.) Solubility: DMSO (Slightly), Methanol (Slightly) Method for Determining Identity: Proton NMR (DMSO-d6) and Mass Spectrometric Analysis TLC Conditions: SiO2, Dichloromethane: Methanol=9.1, Visualized with UV and AMCS, Single spot, Rf=0.50 Elemental Analysis: Calculated: %C: 66.17%, %H: 4.44 Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures. |
