Neuropeptide Y (NPY), a neuropeptide colocalized and abundantly released with the neurotransmitter norepinephrine in nervous system, synthesized by postnatal olfactory epithelium of sustentacular cells. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. NPY precursor is a 97-aa peptide in mouse, human (chr 7p15.1) and 98-aa in rat has a mol. wt of 11kD. The precursor contains a 28-aa signal peptide, 29-64 (active processed NPY peptide) followed by the C-flanking peptide of NPY. NPY shows sequence homology to Peptide YY (PYY) and over 50% homology in amino acid and nucleotide sequence to Pancreatic Polypeptide (PNP or PPY), all of these homologous peptides has a 36-aa mature peptide characterized by a hairpin loop. Source: 9aa peptide from Mouse NPY1 (1) Epitope Location: ~N-terminus of mature NPY Species Sequence Homology: Chicken, human, rat-100%. Applications: Suitable for use in ELISA as a control peptide for N2176-60K. Other applications not tested. Recommended Dilution: ELISA: Coat ELISA plates at 1ug/ml. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
Purified
Form:
Supplied as a lyophilized powder from PBS, 0.05% sodium azide.
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