Neurotensin Receptor 3, Control Peptide, Human (NTR3, Sortilin)
Biozol Catalog Number:
USB-N2177-50
Supplier Catalog Number:
N2177-50
Alternative Catalog Number:
USB-N2177-50-100
Manufacturer:
US Biological
Category:
Molekularbiologie
Application:
ELISA, WB
Control Peptide for N2177-51 (antiserum) and N2177-51 (affinity purified) An 18 aa peptide sequence close to the extracellular, N-terminus region of human NTR3 . Neurotensin (NT) is an endogenous tridecapeptide neurotransmitter that influences distinct central and peripheral physiological functions in mammals. Central administration of NT modulates dopaminergic transmission and triggers hypothermic and naloxone-insensitive analgesic responses, whereas peripheral effects include hypotension, decrease gastric acid release, potentiation of lipid digestion. NT is widely distributed throughout the CNS. It has been localized to catecholamine-containing neurons. NT initiates its biological action by interacting with two distinct G-protein coupled receptors (NTR1 and NTR2). Recently, a third receptor NTR3 has been identified that is identical to gp95/sortilin and it is not coupled via the G-proteins. All three receptors bind NT through its C-terminal hexapeptide sequence (8 RRPYIL 13). Biologically active NT (NT8-13) has also been shown to interact with the extracellular domain 3 (between TM6-7) of NTR1. Most recently, a novel, non-GPCR, NTR3/sortilin/gp95/NT3 (mouse 825 aa, rat 748 aa, human 833 aa, chromosome 1p21.3, ~92% identity between human and mouse) also binds NT. Sortilin was initially isolated as by its affinity for receptor-associated protein (RAP). NTR3, the first non-GPCR neuropeptides receptor, sequence includes a putative secretory signal peptide, a furin cleavage site, and a single transmembrane domain near the C-terminus. The mature protein has 44 N-terminal residues removed during processing. It is homologous to the yeast protein Vps10p and the human sortilin-related receptor. The C terminus of the protein contains a lysosomal sorting motif shared by the mannose-6-phosphate receptors. NTR3 is expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta, and testis.
Purity:
Highly purified
Form:
Supplied as a liquid in PBS, pH 7.2
* VAT and and shipping costs not included. Errors and price changes excepted
